Enter medications to view a detailed interaction report using our drug interaction checker. For example, phenytoin, carbamazepine, and phenobarbital (or primidone) can double the clearance of valproate. The exact mechanisms by which valproate exerts it's effects on epilepsy, migraine headaches, and bipolar disorder are unknown however several pathways exist which may contribute to the drug's action.
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Many of these interactions are reciprocal and may have important therapeutic consequences
Valproate acts as a protein binding displacer and/or metabolic inhibitor with respect to a number of other anticonvulsants (phenobarbitone, primidone, phenytoin).
Nhs medicines information on possible interactions with sodium valproate and other medicines, herbal remedies and supplements. See the list of drugs that interact with valproate Includes information on severity of interaction and the level of evidence for it. Drugs that affect the level of expression of hepatic enzymes, particularly those that elevate levels of glucuronosyltransferases, may increase the clearance of valproate
