Mucus is used to trap foreign substances that enter the body The mucosa of the nasal cavity prepares inhaled air for arrival at the lower respiratory system It moves them up the trachea towards pharynx to be swallowed into the stomach
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Cilia on the walls moves mucus towards pharnyx so it can be swallowed by to the stomach.
Nasal route gives good absorption of small molecules, than that of large molecules can be increased by absorption promoters
In this article an overview of intranasal drug delivery with its various aspects like factors affecting nasal absorption, strategies to improve bioavailability are discussed. Nasal mucus acts as a natural filter, trapping airborne particles, dust, allergens, and pathogens that enter the nasal cavity during breathing This filtration process prevents harmful substances from reaching the lungs and causing respiratory infections or allergic reactions. This lining is covered by a thin layer of mucus, which helps maintain hydration and acts as a barrier
Rich in blood supply, it is sensitive to environmental changes and easily responds to irritants. There are many attractive reasons to introduce a drug via the nasal route of administration as a convenient accessible route which achieves localized and systemic actions rapidly and manageably. “the nose has many important tasks that we are not aware of, and the mucous membrane, with its outermost layer of mucus, is essential for all of them,” says pär stjärne The nose is not only part of the immune system where it traps particles, viruses and bacteria in the snot.
It is very thin in the meatuses on the floor of the nasal cavities, and in the various sinuses
It is one of the most commonly infected tissues in adults and children. As air passes over the nasal mucosa, it is prepared or conditioned to safely pass deeper into the respiratory system The heat radiated from the blood vessels in the lamina propria warms the air to near body temperature. The nasal mucosa filters inhaled air, trapping particles and pathogens in the mucus
The moisture provided by the mucus also humidifies the incoming air, protecting the delicate tissues of the lower respiratory tract.
