The direct mode of action of enzalutamide has been shown to translate into clinical responses in patients with mcrpc. Results from the randomised, phase 3 affirm trial. Enzalutamide, the first approved ar signalling inhibitor, has a novel mode of action targeting ar signalling at three key stages.
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Enzalutamide is the first approved ar signalling inhibitor (also described as an ar inhibitor), with a novel mechanism of action, that distinguishes it from both androgen biosynthesis inhibitors (e.g
