G6pd deficiency correlates remarkably, in its geographic distribution, with past/present malaria endemicity The gene that causes g6pd deficiency (g6pd) is located on the x chromosome However, heterozygous females are actually the more common genotype
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A female who has a mutant g6pd gene on one of her x chromosomes is a carrier for g6pd deficiency
She usually has a normal copy of g6pd gene on the other x chromosome that produces sufficient g6pd to protect the red blood cells.
