Its mechanism of action involves the binding to g protein coupled pge1 receptors localized on the surface of smooth muscle cells, thus activating camp (cyclic adenosine monophosphate), which in turn induces penile vascular smooth muscle relaxation to provide penile erection. The mechanism of action of alprostadil is as a prostaglandin receptor agonist Alprostadil works by binding to specific receptors on the surface of cells, activating the enzyme adenylate cyclase
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This activation increases the levels of cyclic adenosine monophosphate (camp) within the cells.
Alprostadil (pge1) is a prostaglandin with a wide variety of pharmacological actions including vasodilation and inhibition of platelet aggregation.
Alprostadil induces erection by relaxation of trabecular smooth muscle and by dilation of This leads to expansion of lacunar spaces and entrapment of blood. Alprostadil exerts its effects by mimicking the action of prostaglandin e1 (pge1), a naturally occurring substance in the body The mechanism of action involves
Alprostadil binds to prostaglandin receptors on smooth muscle cells, activating adenylate cyclase. [7] [8] alprostadil induces vasodilation through a direct effect on vascular and ductus arteriosus smooth muscle
